Do not, under any circumstances, use any leftover trepanation to introduce two mythologies, one upper and one downer.

You will find the contradiction too much to withstand. Every time you think you have the exuberance down, the shards of lugubriousness will infiltrate your once cozy tubules, making breathing hard.

Trepanations are not to be used for this. Inhalation, injection, ingestion are more than sufficient